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How Long Does Tadalafil Stay in Your System? Whether you take Tadalafil for erectile dysfunction, benign prostatic hyperplasia, or off-label purposes, it’s natural to wonder how long Tadalafil stays in your system. Understanding its lifespan in your body can help you plan dosing, anticipate side effects, and comply with any medical or legal requirements for drug testing. In this guide, we’ll explain the science behind Tadalafil half-life, discuss how long Tadalafil lasts, and explore factors that influence detection time—all in easy-to-understand language. What Is the Half-Life of Tadalafil? The half-life of a drug is the time it takes for half of the dose to be eliminated from your bloodstream. For Tadalafil, the reported half-life is approximately 17.5 hours. This relatively long half-life explains why Tadalafil’s effects can persist for up to 36 hours, earning it the nickname “the weekend pill.” After one half-life (17.5 hours), only 50 percent of the original dose remains acti

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